Insights into Ciliary Genes and Evolution from Multi-Level Phylogenetic Profiling.

ABSTRACT: Cilia (flagella) are important eukaryotic organelles, present in the Last Eukaryotic Common Ancestor, and are involved in cell motility and integration of extracellular signals. Ciliary dysfunction causes a class of genetic diseases, known as ciliopathies, however current knowledge of the underlying mechanisms is still limited and a better characterization of genes is needed. As cilia have been lost independently several times during evolution and they are subject to important functional variation between species, ciliary genes can be investigated through comparative genomics. We performed phylogenetic profiling by predicting orthologs of human protein-coding genes in 100 eukaryotic species. The analysis integrated three independent methods to predict a consensus set of 274 ciliary genes,

SUBMITTER: Nevers Y 

PROVIDER: S-EPMC5850483 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature