Adult adiposity and risk of early menopause.

ABSTRACT:

Study question

Is adult adiposity associated with early menopause?

Summary answer

Overall and abdominal adiposity were non-linearly associated with odds for early natural menopause with elevated odds observed among women who were underweight in early or mid-adulthood compared to lean-normal weight women.

What is known already

High and low adiposity have been associated with reproductive function and may potentially impact timing of menopause. It is unclear whether various aspects of adiposity are associated with risk of early menopause.

Study design, size, duration

Prospective cohort study that examined data from 78 759 premenopausal women from the Nurses' Health Study II who were followed from 1989 to 2011 for incidence of early natural menopause.

Participa

SUBMITTER: Szegda KL 

PROVIDER: S-EPMC5850492 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature