Disentangling Immediate Adaptive Introgression from Selection on Standing Introgressed Variation in Humans.

ABSTRACT: Recent studies have reported evidence suggesting that portions of contemporary human genomes introgressed from archaic hominin populations went to high frequencies due to positive selection. However, no study to date has specifically addressed the postintrogression population dynamics of these putative cases of adaptive introgression. Here, for the first time, we specifically define cases of immediate adaptive introgression (iAI) in which archaic haplotypes rose to high frequencies in humans as a result of a selective sweep that occurred shortly after the introgression event. We define these cases as distinct from instances of selection on standing introgressed variation (SI), in which an introgressed haplotype initially segregated neutrally and subsequently underwent positive selection. U

SUBMITTER: Jagoda E 

PROVIDER: S-EPMC5850494 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature