Faster Evolving Primate Genes Are More Likely to Duplicate.

ABSTRACT: An attractive and long-standing hypothesis regarding the evolution of genes after duplication posits that the duplication event creates new evolutionary possibilities by releasing a copy of the gene from constraint. Apparent support was found in numerous analyses, particularly, the observation of higher rates of evolution in duplicated as compared with singleton genes. Could it, instead, be that more duplicable genes (owing to mutation, fixation, or retention biases) are intrinsically faster evolving? To uncouple the measurement of rates of evolution from the determination of duplicate or singleton status, we measure the rates of evolution in singleton genes in outgroup primate lineages but classify these genes as to whether they have duplicated or not in a crown group of great apes. We fi

SUBMITTER: O'Toole AN 

PROVIDER: S-EPMC5850500 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature