Dosing guidance for intravenous colistin in critically-ill patients.

ABSTRACT:

Background

Intravenous colistin is difficult to use because plasma concentrations for antibacterial effect overlap those causing nephrotoxicity, and there is large inter-patient variability in pharmacokinetics. The aim was to develop dosing algorithms for achievement of a clinically desirable average steady-state plasma colistin concentration (C_ss,avg) of 2mg/L.

Methods

Plasma concentration-time data from 214 adult critically-ill patients (creatinine clearance 0-236mL/min; 29 receiving renal replacement therapy (RRT)) were subjected to population pharmacokinetic analysis. Development of an algorithm for patients not receiving RRT was based upon the relationship between the dose of colistimethate that would be needed to achieve a desired C_ss,avg and crea

SUBMITTER: Nation RL 

PROVIDER: S-EPMC5850520 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature