Long-term Mortality of Patients With Tuberculous Meningitis in New York City: A Cohort Study.

ABSTRACT:

Background

Tuberculous meningitis (TBM) is the most devastating clinical presentation of infection with Mycobacterium tuberculosis; delayed initiation of effective antituberculosis therapy is associated with poor treatment outcomes. Our objective was to determine the relationship between drug resistance and 10-year mortality among patients with TBM.

Methods

We conducted a retrospective cohort study of 324 patients with culture-confirmed TBM, susceptibility results reported for isoniazid and rifampin, and initiation of at least 2 antituberculosis drugs, reported to the tuberculosis registry in New York City between 1 January 1992 and 31 December 2001. Date of death was ascertained by matching the tuberculosis registry with death certificate data for 1992-2012 from the New Yor

SUBMITTER: Vinnard C 

PROVIDER: S-EPMC5850536 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature