Effect of randomized serum progesterone concentration on secretory endometrial histologic development and gene expression.

ABSTRACT:

Study question

What doses of secretory phase progesterone (P) in women are associated with altered endometrial structure and/or function?

Summary answer

Consistently delayed histological maturation was seen at the lowest tested daily P dose (2.5 mg), whereas consistently altered functional response, as reflected by microarray analysis of gene expression was seen at both the 5 and 2.5 mg doses.

What is known already

Progesterone is absolutely required for normal embryo implantation and pregnancy survival. Progesterone supplementation is beneficial in ART cycles.

Study design, size, duration

In this case-control experimental trial, 46 healthy young female volunteers (age 19-34) underwent a single modeled endometrial cycle after GnRH down-regulation or monitored i

SUBMITTER: Young SL 

PROVIDER: S-EPMC5850604 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature