Effects of Demographic History on the Detection of Recombination Hotspots from Linkage Disequilibrium.

ABSTRACT: In some species, meiotic recombination is concentrated in small genomic regions. These "recombination hotspots" leave signatures in fine-scale patterns of linkage disequilibrium, raising the prospect that the genomic landscape of hotspots can be characterized from sequence variation. This approach has led to the inference that hotspots evolve rapidly in some species, but are conserved in others. Historic demographic events, such as population bottlenecks, are known to affect patterns of linkage disequilibrium across the genome, violating population genetic assumptions of this approach. Although such events are prevalent, demographic history is generally ignored when making inferences about the evolution of recombination hotspots. To determine the effect of demography on the detection of re

SUBMITTER: Dapper AL 

PROVIDER: S-EPMC5850621 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature