Macrofilaricidal Efficacy of Repeated Doses of Ivermectin for the Treatment of River Blindness.

ABSTRACT:

Background

Mass drug administration (MDA) with ivermectin is the cornerstone of efforts to eliminate human onchocerciasis by 2020 or 2025. The feasibility of elimination crucially depends on the effects of multiple ivermectin doses on Onchocerca volvulus. A single ivermectin (standard) dose clears the skin-dwelling microfilarial progeny of adult worms (macrofilariae) and temporarily impedes the release of such progeny by female macrofilariae, but a macrofilaricidal effect has been deemed minimal. Multiple doses of ivermectin may cumulatively and permanently reduce the fertility and shorten the lifespan of adult females. However, rigorous quantification of these effects necessitates interrogating longitudinal data on macrofilariae with suitably powerful analytical techniques.

Met

SUBMITTER: Walker M 

PROVIDER: S-EPMC5850622 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature