Association of Obesity, Diabetes, and Risk of Tuberculosis: Two Population-Based Cohorts.

ABSTRACT:

Background

Mounting data have revealed that body mass index (BMI) is inversely associated with risk of active tuberculosis. The inverse association presents a "paradox" with regard to diabetes, because obesity is a major determinant of diabetes, and diabetes is a well-known risk factor for tuberculosis.

Methods

We conducted 2 population-based cohort studies involving 167392 participants. The main exposure was BMI and diabetes ascertained at baseline. Occurrence of incident tuberculosis was ascertained from Taiwan's National Tuberculosis Registry. We conducted a causal mediation analysis and a joint effects analysis to characterize the relationship between BMI, diabetes, and tuberculosis.

Results

During a median of >7 years of follow-up, 491 individuals developed incid

SUBMITTER: Lin HH 

PROVIDER: S-EPMC5850624 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature