Long-term health in recipients of transplanted in vitro propagated spermatogonial stem cells.

ABSTRACT:

Study question

Is testicular transplantation of in vitro propagated spermatogonial stem cells associated with increased cancer incidence and decreased survival rates in recipient mice?

Summary answer

Cancer incidence was not increased and long-term survival rate was not altered after transplantation of in vitro propagated murine spermatogonial stem cells (SSCs) in busulfan-treated recipients as compared to non-transplanted busulfan-treated controls.

What is known already

Spermatogonial stem cell autotransplantation (SSCT) is a promising experimental reproductive technique currently under development to restore fertility in male childhood cancer survivors. Most preclinical studies have focused on the proof-of-principle of the functionality and efficiency of this techni

SUBMITTER: Mulder CL 

PROVIDER: S-EPMC5850721 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature