Recombination Alters the Dynamics of Adaptation on Standing Variation in Laboratory Yeast Populations.

ABSTRACT: The rates and selective effects of beneficial mutations, together with population genetic factors such as population size and recombination rate, determine the outcomes of adaptation and the signatures this process leaves in patterns of genetic diversity. Previous experimental studies of microbial evolution have focused primarily on initially clonal populations, finding that adaptation is characterized by new strongly selected beneficial mutations that sweep rapidly to fixation. Here, we study evolution in diverse outcrossed yeast populations, tracking the rate and genetic basis of adaptation over time. We combine time-serial measurements of fitness and allele frequency changes in 18 populations of budding yeast evolved at different outcrossing rates to infer the drivers of adaptation on s

SUBMITTER: Kosheleva K 

PROVIDER: S-EPMC5850740 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature