Preconception urinary phthalate concentrations and sperm DNA methylation profiles among men undergoing IVF treatment: a cross-sectional study.

ABSTRACT:

Study question

Are preconception phthalate and phthalate replacements associated with sperm differentially methylated regions (DMRs) among men undergoing IVF?

Summary answer

Ten phthalate metabolites were associated with 131 sperm DMRs that were enriched in genes related to growth and development, cell movement and cytoskeleton structure.

What is known already

Several phthalate compounds and their metabolites are known endocrine disrupting compounds and are pervasive environmental contaminants. Rodent studies report that prenatal phthalate exposures induce sperm DMRs, but the influence of preconception phthalate exposure on sperm DNA methylation in humans is unknown.

Study design, size, duration

An exploratory cross-sectional study with 48 male participants fro

SUBMITTER: Wu H 

PROVIDER: S-EPMC5850785 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature