StarBEAST2 Brings Faster Species Tree Inference and Accurate Estimates of Substitution Rates.

ABSTRACT: Fully Bayesian multispecies coalescent (MSC) methods like *BEAST estimate species trees from multiple sequence alignments. Today thousands of genes can be sequenced for a given study, but using that many genes with *BEAST is intractably slow. An alternative is to use heuristic methods which compromise accuracy or completeness in return for speed. A common heuristic is concatenation, which assumes that the evolutionary history of each gene tree is identical to the species tree. This is an inconsistent estimator of species tree topology, a worse estimator of divergence times, and induces spurious substitution rate variation when incomplete lineage sorting is present. Another class of heuristics directly motivated by the MSC avoids many of the pitfalls of concatenation but cannot be used to e

SUBMITTER: Ogilvie HA 

PROVIDER: S-EPMC5850801 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature