In Silico Analysis of Differential Gene Expression in Three Common Rat Models of Diastolic Dysfunction.

ABSTRACT: Standard therapies for heart failure with preserved ejection fraction (HFpEF) have been unsuccessful, demonstrating that the contribution of the underlying diastolic dysfunction pathophysiology differs from that of systolic dysfunction in heart failure and currently is far from being understood. Complicating the investigation of HFpEF is the contribution of several comorbidities. Here, we selected three established rat models of diastolic dysfunction defined by three major risk factors associated with HFpEF and researched their commonalities and differences. The top differentially expressed genes in the left ventricle of Dahl salt sensitive (Dahl/SS), spontaneous hypertensive heart failure (SHHF), and diabetes 1 induced HFpEF models were derived from published data in Gene Expression Omnib

SUBMITTER: Altara R 

PROVIDER: S-EPMC5850854 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature