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The testicular transcriptome associated with spermatogonia differentiation initiated by gonadotrophin stimulation in the juvenile rhesus monkey (Macaca mulatta).


ABSTRACT:

SUBMITTER: Ramaswamy S 

PROVIDER: S-EPMC5850871 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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The testicular transcriptome associated with spermatogonia differentiation initiated by gonadotrophin stimulation in the juvenile rhesus monkey (Macaca mulatta).

Ramaswamy Suresh S   Walker William H WH   Aliberti Paula P   Sethi Rahil R   Marshall Gary R GR   Smith Alyxzandria A   Nourashrafeddin Seyedmehdi S   Belgorosky Alicia A   Chandran Uma R UR   Hedger Mark P MP   Plant Tony M TM  

Human reproduction (Oxford, England) 20171001 10


<h4>Study question</h4>What is the genetic landscape within the testis of the juvenile rhesus monkey (Macaca mulatta) that underlies the decision of undifferentiated spermatogonia to commit to a pathway of differentiation when puberty is induced prematurely by exogenous LH and FSH stimulation?<h4>Summary answer</h4>Forty-eight hours of gonadotrophin stimulation of the juvenile monkey testis resulted in the appearance of differentiating B spermatogonia and the emergence of 1362 up-regulated and 2  ...[more]

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