An integrated approach to infer cross-talks between intracellular protein transport and signaling pathways.

ABSTRACT:

Background

The endomembrane system, known as secretory pathway, is responsible for the synthesis and transport of protein molecules in cells. Therefore, genes involved in the secretory pathway are essential for the cellular development and function. Recent scientific investigations show that ER and Golgi apparatus may provide a convenient drug target for cancer therapy. On the other hand, it is known that abundantly expressed genes in different cellular organelles share interconnected pathways and co-regulate each other activities. The cross-talks among these genes play an important role in signaling pathways, associated to the regulation of intracellular protein transport.

Results

In the present study, we device an integrated approach to understand these complex interaction

SUBMITTER: Tripathi KP 

PROVIDER: S-EPMC5850946 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature