Pathway analysis of transcriptomic data shows immunometabolic effects of vitamin D.

ABSTRACT: Unbiased genomic screening analyses have highlighted novel immunomodulatory properties of the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)₂D). However, clearer interpretation of the resulting gene expression data is limited by cell model specificity. The aim of the current study was to provide a broader perspective on common gene regulatory pathways associated with innate immune responses to 1,25(OH)₂D, through systematic re-interrogation of existing gene expression databases from multiple related monocyte models (the THP-1 monocytic cell line (THP-1), monocyte-derived dendritic cells (DCs) and monocytes). Vitamin D receptor (VDR) expression is common to multiple immune cell types, and thus, pathway analysis of gene expression using data from multiple r

SUBMITTER: Munoz Garcia A 

PROVIDER: S-EPMC5850959 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature