Chylomicrons stimulate incretin secretion in mouse and human cells.

ABSTRACT:

Aims/hypothesis

Lipids are a potent stimulus for the secretion of glucagon-like peptide (GLP)-1 and glucose-dependent insulinotropic peptide (GIP). Traditionally, this effect was thought to involve the sensing of lipid digestion products by free fatty acid receptor 1 (FFA1) and G-protein coupled receptor 119 (GPR119) on the apical surface of enteroendocrine cells. However, recent evidence suggests that lipids may in fact be sensed basolaterally, and that fatty acid absorption and chylomicron synthesis may be a prerequisite for their stimulatory effect on gut peptide release. Therefore, we investigated the effect of chylomicrons on GLP-1 and GIP secretion in vitro.

Methods

The effect of chylomicrons on incretin secretion was investigated using GLUTag cells and duodenal cultur

SUBMITTER: Psichas A 

PROVIDER: S-EPMC5850988 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature