Complement system contributes to modulate the infectivity of susceptible TcI strains of Trypanosoma cruzi.

ABSTRACT:

Background

Trypanosoma cruzi is a protozoan parasite and an etiological agent of Chagas disease. There is a wide variability in the clinical outcome of its infection, ranging from asymptomatic individuals to those with chronic fatal mega syndromes. Both parasite and host factors, as well as their interplay, are thought to be involved in the process.

Objectives

To evaluate the resistance to complement-mediated killing in two T. cruzi TcI strains with differential virulence and the subsequent effect on their infectivity in mammalian cells.

Methods

Tissue-culture derived trypomastigotes of both strains were incubated in guinea pig serum and subjected to flow cytometry in order to determine their viability and complement activations. Trypomastigotes were also incubated on

SUBMITTER: Arroyo-Olarte RD 

PROVIDER: S-EPMC5851054 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature