¹¹C-DPA-713 has much greater specific binding to translocator protein 18 kDa (TSPO) in human brain than ¹¹C-( R)-PK11195.

ABSTRACT: Positron emission tomography (PET) radioligands for translocator protein 18 kDa (TSPO) are widely used to measure neuroinflammation, but controversy exists whether second-generation radioligands are superior to the prototypical agent ¹¹C-( R)-PK11195 in human imaging. This study sought to quantitatively measure the "signal to background" ratio (assessed as binding potential ( BP_ND)) of ¹¹C-( R)-PK11195 compared to one of the most promising second-generation radioligands, ¹¹C-DPA-713. Healthy subjects had dynamic PET scans and arterial blood measurements of radioligand after injection of either ¹¹C-( R)-PK11195 (16 subjects) or ¹¹C-DPA-713 (22 subjects). To measure the amount of specific binding, a subset of these subjects wa

SUBMITTER: Kobayashi M 

PROVIDER: S-EPMC5851139 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature