Predictive validity of biochemical biomarkers in knee osteoarthritis: data from the FNIH OA Biomarkers Consortium.

ABSTRACT:

Objective

To investigate a targeted set of biochemical biomarkers as predictors of clinically relevant osteoarthritis (OA) progression.

Methods

Eighteen biomarkers were measured at baseline, 12 months (M) and 24 M in serum (s) and/or urine (u) of cases (n=194) from the OA initiative cohort with knee OA and radiographic and persistent pain worsening from 24 to 48 M and controls (n=406) not meeting both end point criteria. Primary analyses used multivariable regression models to evaluate the association between biomarkers (baseline and time-integrated concentrations (TICs) over 12 and 24 M, transposed to z values) and case status, adjusted for age, sex, body mass index, race, baseline radiographic joint space width, Kellgren-Lawrence grade, pain and pain medication use. For bi

SUBMITTER: Kraus VB 

PROVIDER: S-EPMC5851287 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature