Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study.

ABSTRACT: Previous findings on the association of genetic factors and pancreatic cancer survival are limited and inconsistent. In a two-stage study, we analyzed the existing genome-wide association study dataset of 868 pancreatic cancer patients from MD Anderson Cancer Center in relation to overall survival using Cox regression. Top hits were selected for replication in another 820 patients from the same institution using the Taqman genotyping method. Functional annotation, pathway analysis and gene expression analysis were conducted using existing software and databases. We discovered genome-wide significant associations of patient survival with three imputed SNPs which, in complete LD (r²  = 1), were intronic SNPs of the PAIP2B (rs113988120) and DYSF genes (rs112493246 and rs138529893)

SUBMITTER: Tang H 

PROVIDER: S-EPMC5851439 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature