Directed γ-C(sp³)-H Alkylation of Carboxylic Acid Derivatives through Visible Light Photoredox Catalysis.

ABSTRACT: Visible light photoredox catalysis enables direct γ- C(sp³)-H alkylation of saturated aliphatic carbonyl compounds. Electron-deficient alkenes are used as the coupling partners in this reaction. Distinguished site selectivity is controlled by the predominant 1,5-hydrogen atom transfer of an amidyl radical generated in situ.

SUBMITTER: Chen DF 

PROVIDER: S-EPMC5851452 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature