GABRA2, alcohol, and illicit drug use: An event-level model of genetic risk for polysubstance use.

ABSTRACT: GABRA2, the gene encoding the α2 subunit of the GABAA receptor, potentially plays a role in the etiology of problematic drinking, as GABRA2 genotype has been associated with subjective response to alcohol and other alcohol-related reward processes. The GABRA2 gene has also been associated with illicit drug use, but the extent to which associations with drug use are independent of associations with alcohol use remains unclear, partly because most previous research has used a cross-sectional design that cannot discriminate comorbidity at the between-person level and co-occurrence within-persons. The present study used a daily monitoring method that assessed the effects of GABRA2 variation on substance use as it occurred in the natural environment during emerging adulthood. Non-Hispanic Europ

SUBMITTER: Mallard TT 

PROVIDER: S-EPMC5851473 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature