Nicotine Abstinence Influences the Calculation of Salience in Discrete Insular Circuits.

ABSTRACT:

Background

Insular subdivisions show distinct patterns of resting-state functional connectivity (rsFC) with specific brain regions, each with different functional significance. Seeds in these subdivisions are employed to characterize the effects of acute nicotine abstinence on rsFC between insula subdivisions and brain networks implicated in addiction and attentional control.

Methods

In a within-subjects design, resting-state blood oxygen level-dependent data were collected from treatment-seeking smokers (N= 20) following smoking satiety and again following 48 hours of nicotine abstinence. Three right hemisphere insular regions of interest (dorsal, ventral, and posterior) served as seeds for analyses. Indices of both static and dynamic rsFC were obtained and correlated with

SUBMITTER: Fedota JR 

PROVIDER: S-EPMC5851477 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature