Changes in resting-state functional connectivity after stroke in a mouse brain lacking extracellular matrix components.

ABSTRACT: In the brain, focal ischemia results in a local region of cell death and disruption of both local and remote functional neuronal networks. Tissue reorganization following stroke can be limited by factors such as extracellular matrix (ECM) molecules that prevent neuronal growth and synaptic plasticity. The brain's ECM plays a crucial role in network formation, development, and regeneration of the central nervous system. Further, the ECM is essential for proper white matter tract development and for the formation of structures called perineuronal nets (PNNs). PNNs mainly surround parvalbumin/GABA inhibitory interneurons, of importance for processing sensory information. Previous studies have shown that downregulating PNNs after stroke reduces the neurite-inhibitory environment, reactivates p

SUBMITTER: Quattromani MJ 

PROVIDER: S-EPMC5851486 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature