Pitx2 regulates cardiac left-right asymmetry by patterning second cardiac lineage-derived myocardium.

ABSTRACT: Current models of left-right asymmetry hold that an early asymmetric signal is generated at the node and transduced to lateral plate mesoderm in a linear signal transduction cascade through the function of the Nodal signaling molecule. The Pitx2 homeobox gene functions at the final stages of this cascade to direct asymmetric morphogenesis of selected organs including the heart. We previously showed that Pitx2 regulated an asymmetric pathway that was independent of cardiac looping suggesting a second asymmetric cardiac pathway. It has been proposed that in the cardiac outflow tract Pitx2 functions in both cardiac neural crest, as a target of canonical Wnt-signaling, and in the mesoderm-derived cardiac second lineage. We used fate mapping, conditional loss of function, and chimera analysis i

SUBMITTER: Ai D 

PROVIDER: S-EPMC5851592 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature