Impact of ageing and a synbiotic on the immune response to seasonal influenza vaccination; a randomised controlled trial.

ABSTRACT:

Background & aims

Ageing increases risk of respiratory infections and impairs the response to influenza vaccination. Pre- and pro-biotics offer an opportunity to modulate anti-viral defenses and the response to vaccination via alteration of the gut microbiota. This study investigated the effect of a novel probiotic, Bifidobacterium longum bv. infantis CCUG 52486, combined with a prebiotic, gluco-oligosaccharide, on the B and T cell response to seasonal influenza vaccination in young and older subjects .

Methods

In a double-blind, randomized controlled trial, 58 young (18-35 y) and 54 older (60-85 y) subjects were supplemented with the synbiotic for 8 weeks. At 4 weeks they were administered with a seasonal influenza vaccine. B and T cell phenotype and responsiveness to in vi

SUBMITTER: Enani S 

PROVIDER: S-EPMC5851674 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature