Prediction for sustained deep molecular response of BCR-ABL1 levels in patients with chronic myeloid leukemia in chronic phase.

ABSTRACT:

Background

The achievement of a sustained deep molecular response is a goal of increasing relevance because it opens the possibility of treatment discontinuation. The objective of this analysis was to develop a prediction model for a sustained molecular response with BCR-ABL1 level <0.0032% on the international scale (MR^4.5 ) for at least 2 years according to BCR-ABL1 levels achieved within the first 12 months of therapy.

Methods

Data for 603 patients with newly diagnosed chronic myeloid leukemia in chronic phase in consecutive prospective clinical trials were analyzed. The best fit average molecular response was defined by robust linear regression models, with which the average molecular levels were defined. The minimum acceptable molecular response was defined b

SUBMITTER: Sasaki K 

PROVIDER: S-EPMC5851790 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature