Oxygen Exposure Resulting in Arterial Oxygen Tensions Above the Protocol Goal Was Associated With Worse Clinical Outcomes in Acute Respiratory Distress Syndrome.

ABSTRACT:

Objectives

High fractions of inspired oxygen may augment lung damage to exacerbate lung injury in patients with acute respiratory distress syndrome. Participants enrolled in Acute Respiratory Distress Syndrome Network trials had a goal partial pressure of oxygen in arterial blood range of 55-80 mm Hg, yet the effect of oxygen exposure above this arterial oxygen tension range on clinical outcomes is unknown. We sought to determine if oxygen exposure that resulted in a partial pressure of oxygen in arterial blood above goal (> 80 mm Hg) was associated with worse outcomes in patients with acute respiratory distress syndrome.

Design

Longitudinal analysis of data collected in these trials.

Setting

Ten clinical trials conducted at Acute Respiratory Distress Syndrome Network

SUBMITTER: Aggarwal NR 

PROVIDER: S-EPMC5851805 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature