A robust and powerful two-step testing procedure for local ancestry adjusted allelic association analysis in admixed populations.

ABSTRACT: Genetic association studies in admixed populations allow us to gain deeper understanding of the genetic architecture of human diseases and traits. However, population stratification, complicated linkage disequilibrium (LD) patterns, and the complex interplay of allelic and ancestry effects on phenotypic traits pose challenges in such analyses. These issues may lead to detecting spurious associations and/or result in reduced statistical power. Fortunately, if handled appropriately, these same challenges provide unique opportunities for gene mapping. To address these challenges and to take these opportunities, we propose a robust and powerful two-step testing procedure Local Ancestry Adjusted Allelic (LAAA) association. In the first step, LAAA robustly captures associations due to allelic ef

SUBMITTER: Duan Q 

PROVIDER: S-EPMC5851818 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature