Promoting effects of adipose-derived stem cells on breast cancer cells are reversed by radiation therapy.

ABSTRACT: Partial breast irradiation of early breast cancer patients after lumpectomy and the use of endogenous adipose tissue (AT) for breast reconstruction are promising applications to reduce the side effects of breast cancer therapy. This study tries to investigate the possible risks associated with these therapeutic approaches. It also examines the influence of adipose derived stem cells (ADSCs) as part of the breast cancer microenvironment, and endogenous AT on breast cancer cells following radiation therapy. ADSCs, isolated from human reduction mammoplasties of healthy female donors, exhibited multilineage capacity and specific surface markers. The promoting effects of ADSCs on the growth and survival fraction of breast cancer cells were reversed by treatment with high (8 Gy) or medium (2 Gy)

SUBMITTER: Baaße A 

PROVIDER: S-EPMC5851964 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature