Predicting the spatiotemporal diversity of seizure propagation and termination in human focal epilepsy.

ABSTRACT: Recent studies have shown that seizures can spread and terminate across brain areas via a rich diversity of spatiotemporal patterns. In particular, while the location of the seizure onset area is usually invariant across seizures in an individual patient, the source of traveling (2-3 Hz) spike-and-wave discharges during seizures can either move with the slower propagating ictal wavefront or remain stationary at the seizure onset area. Furthermore, although many focal seizures terminate synchronously across brain areas, some evolve into distinct ictal clusters and terminate asynchronously. Here, we introduce a unifying perspective based on a new neural field model of epileptic seizure dynamics. Two main mechanisms, the co-existence of wave propagation in excitable media and coupled-oscillat

SUBMITTER: Proix T 

PROVIDER: S-EPMC5852068 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature