Role of Murine Complement Component C5 in Acute in Vivo Infection by Pathogenic Leptospira interrogans.

ABSTRACT: Leptospirosis is considered one of the most important zoonosis worldwide. The activation of the Complement System is important to control dissemination of several pathogens in the host. Only a few studies have employed murine models to investigate leptospiral infection and our aim in this work was to investigate the role of murine C5 during in vivo infection, comparing wild type C57BL/6 (B6 C5^+/+) and congenic C57BL/6 (B6 C5^-/-, C5 deficient) mice during the first days of infection. All animals from both groups survived for at least 8 days post-infection with pathogenic Leptospira interrogans serovar Kennewicki strain Fromm (LPF). At the third day of infection, we observed greater numbers of LPF in the liver of B6 C5^-/- mice when compared to B

SUBMITTER: de Castro IA 

PROVIDER: S-EPMC5852101 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature