An Ontology Systems Approach on Human Brain Expression and Metaproteomics.

ABSTRACT: Research in the last decade has shown growing evidence of the gut microbiota influence on brain physiology. While many mechanisms of this influence have been proposed in animal models, most studies in humans are the result of a pathology-dysbiosis association and very few have related the presence of certain taxa with brain substructures or molecular pathways. In this paper, we associated the functional ontologies in the differential expression of brain substructures from the Allen Brain Atlas database, with those of the metaproteome from the Human Microbiome Project. Our results showed several coherent clustered ontologies where many taxa could influence brain expression and physiology. A detailed analysis of psychobiotics showed specific slim ontologies functionally associated with subst

SUBMITTER: Flores Saiffe Farias A 

PROVIDER: S-EPMC5852110 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature