Synthesis, antimicrobial activity, pharmacophore modeling and molecular docking studies of new pyrazole-dimedone hybrid architectures.

ABSTRACT:

Background

Design and synthesis of pyrazole-dimedone derivatives were described by one-pot multicomponent reaction as new antimicrobial agents. These new molecular framework were synthesized in high yields with a broad substrate scope under benign conditions mediated by diethylamine (NHEt₂). The molecular structures of the synthesized compounds were assigned based on different spectroscopic techniques (¹H-NMR, ¹³C-NMR, IR, MS, and CHN).

Results

The synthesized compounds were evaluated for their antibacterial and antifungal activities against S. aureus ATCC 29213, E. faecalis ATCC29212, B. subtilis ATCC 10400, and C. albicans ATCC 2091 using agar Cup plate method. Compound 4b exhibited the best activity against B. subtilis and E. faecalis with

SUBMITTER: Barakat A 

PROVIDER: S-EPMC5852137 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature