Feasibility and resolution limits of opto-magnetic imaging of neural network activity in brain slices using color centers in diamond.

ABSTRACT: We suggest a novel approach for wide-field imaging of the neural network dynamics of brain slices that uses highly sensitivity magnetometry based on nitrogen-vacancy (NV) centers in diamond. In-vitro recordings in brain slices is a proven method for the characterization of electrical neural activity and has strongly contributed to our understanding of the mechanisms that govern neural information processing. However, this traditional approach only acquires signals from a few positions, which severely limits its ability to characterize the dynamics of the underlying neural networks. We suggest to extend its scope using NV magnetometry-based imaging of the neural magnetic fields across the slice. Employing comprehensive computational simulations and theoretical analyses, we determine the spa

SUBMITTER: Karadas M 

PROVIDER: S-EPMC5852147 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature