A new two-strip TLC method for the quality control of technetium-99m mercaptoacetyl-triglycine (^99mTc-MAG3).

ABSTRACT:

Background

^99mTc-mercaptoacetyl-triglycine (^99mTc-MAG3) has been used for dynamic renal imaging since about 30 years. Free pertechnetate (^99mTcO₄), colloidal ^99mTc ((^99mTcO₂)_n), ^99mTc-tartrate (precursor), precomplexes (^99mTc-(MAG3)_x) and lipophilic ^99mTc-MAG2 are the main radiochemical impurities that may occur in the preparation. The total amount of these impurities has to be identified before release of the product for patient administration to guarantee patient safety and good image quality. The European Pharmacopoeia suggests a method based on high-pressure liquid chromatography analysis in combination with a paper chromatography. This analytical

SUBMITTER: Straub M 

PROVIDER: S-EPMC5852202 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature