Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling.

ABSTRACT: Prior studies identified HLA class-II and 57 additional loci as contributors to genetic susceptibility for type 1 diabetes (T1D). We hypothesized that race and/or ethnicity would be contextually important for evaluating genetic risk markers previously identified from Caucasian/European cohorts. We determined the capacity for a combined genetic risk score (GRS) to discriminate disease-risk subgroups in a racially and ethnically diverse cohort from the southeastern U.S. including 637 T1D patients, 46 at-risk relatives having two or more T1D-related autoantibodies (≥2AAb⁺), 790 first-degree relatives (≤1AAb⁺), 68 second-degree relatives (≤1 AAb⁺), and 405 controls. GRS was higher among Caucasian T1D and at-risk subjects versus ≤ 1AAb⁺ relatives or c

SUBMITTER: Perry DJ 

PROVIDER: S-EPMC5852207 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature