Polygenic signal for symptom dimensions and cognitive performance in patients with chronic schizophrenia.

ABSTRACT: Genetic etiology of psychopathology symptoms and cognitive performance in schizophrenia is supported by candidate gene and polygenic risk score (PRS) association studies. Such associations are reported to be dependent on several factors - sample characteristics, illness phase, illness severity etc. We aimed to examine if schizophrenia PRS predicted psychopathology symptoms and cognitive performance in patients with chronic schizophrenia. We also examined if schizophrenia associated autosomal loci were associated with specific symptoms or cognitive domains. Case-only analysis using data from the Clinical Antipsychotics Trials of Intervention Effectiveness-Schizophrenia trials (n = 730). PRS was constructed using Psychiatric Genomics Consortium (PGC) leave one out genome wide associat

SUBMITTER: Xavier RM 

PROVIDER: S-EPMC5852279 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature