Mixtures of Lipophilic Phycotoxins: Exposure Data and Toxicological Assessment.

ABSTRACT: Lipophilic phycotoxins are secondary metabolites produced by phytoplanktonic species. They accumulate in filter-feeding shellfish and can cause human intoxication. Regulatory limits have been set for individual toxins, and the toxicological features are well characterized for some of them. However, phycotoxin contamination is often a co-exposure phenomenon, and toxicological data regarding mixtures effects are very scarce. Moreover, the type and occurrence of phycotoxins can greatly vary from one region to another. This review aims at summarizing the knowledge on (i) multi-toxin occurrence by a comprehensive literature review and (ii) the toxicological assessment of mixture effects. A total of 79 publications was selected for co-exposure evaluation, and 44 of them were suitable for toxin r

SUBMITTER: Alarcan J 

PROVIDER: S-EPMC5852474 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature