Tissue transglutaminase induction in the pressure-overloaded myocardium regulates matrix remodelling.

ABSTRACT:

Aims

Tissue transglutaminase (tTG) is induced in injured and remodelling tissues, and modulates cellular phenotype, while contributing to matrix cross-linking. Our study tested the hypothesis that tTG may be expressed in the pressure-overloaded myocardium, and may regulate cardiac function, myocardial fibrosis and chamber remodelling.

Methods and results

In order to test the hypothesis, wild-type and tTG null mice were subjected to pressure overload induced through transverse aortic constriction. Moreover, we used isolated cardiac fibroblasts and macrophages to dissect the mechanisms of tTG-mediated actions. tTG expression was upregulated in the pressure-overloaded mouse heart and was localized in cardiomyocytes, interstitial cells, and in the extracellular matrix. In contra

SUBMITTER: Shinde AV 

PROVIDER: S-EPMC5852520 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature