PClass: Protein Quaternary Structure Classification by Using Bootstrapping Strategy as Model Selection.

ABSTRACT: Protein quaternary structure complex is also known as a multimer, which plays an important role in a cell. The dimer structure of transcription factors is involved in gene regulation, but the trimer structure of virus-infection-associated glycoproteins is related to the human immunodeficiency virus. The classification of the protein quaternary structure complex for the post-genome era of proteomics research will be of great help. Classification systems among protein quaternary structures have not been widely developed. Therefore, we designed the architecture of a two-layer machine learning technique in this study, and developed the classification system PClass. The protein quaternary structure of the complex is divided into five categories, namely, monomer, dimer, trimer, tetramer, and oth

SUBMITTER: Huang CC 

PROVIDER: S-EPMC5852587 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature