Local sympathetic denervation attenuates myocardial inflammation and improves cardiac function after myocardial infarction in mice.

ABSTRACT: Aims:Cardiac inflammation has been suggested to be regulated by the sympathetic nervous system (SNS). However, due to the lack of methodology to surgically eliminate the myocardial SNS in mice, neuronal control of cardiac inflammation remains ill-defined. Here, we report a procedure for local cardiac sympathetic denervation in mice and tested its effect in a mouse model of heart failure post-myocardial infarction. Methods and results:Upon preparation of the carotid bifurcation, the right and the left superior cervical ganglia were localized and their pre- and postganglionic branches dissected before removal of the ganglion. Ganglionectomy led to an almost entire loss of myocardial sympathetic innervation in the left ventricular anterior wall. When applied at the time of myocardial infarcti

SUBMITTER: Ziegler KA 

PROVIDER: S-EPMC5852629 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature