Long-Term Follow-up of Monoclonal Gammopathy of Undetermined Significance.

ABSTRACT:

Background

Monoclonal gammopathy of undetermined significance (MGUS) occurs in approximately 3% of persons 50 years of age or older.

Methods

We studied 1384 patients who were residing in southeastern Minnesota and in whom MGUS was diagnosed at the Mayo Clinic in the period from 1960 through 1994; the median follow-up was 34.1 years (range, 0.0 to 43.6). The primary end point was progression to multiple myeloma or another plasma-cell or lymphoid disorder.

Results

During 14,130 person-years of follow-up, MGUS progressed in 147 patients (11%), a rate that was 6.5 times (95% confidence interval [CI], 5.5 to 7.7) as high as the rate in the control population. The risk of progression without accounting for death due to competing causes was 10% at 10 years, 18% at 20 years,

SUBMITTER: Kyle RA 

PROVIDER: S-EPMC5852672 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature