Parsing the heterogeneity of depression: An exploratory factor analysis across commonly used depression rating scales.

ABSTRACT:

Background

Due to the heterogeneity of depressive symptoms-which can include depressed mood, anhedonia, negative cognitive biases, and altered activity levels-researchers often use a combination of depression rating scales to assess symptoms. This study sought to identify unidimensional constructs measured across rating scales for depression and to evaluate these constructs across clinical trials of a rapid-acting antidepressant (ketamine).

Methods

Exploratory factor analysis (EFA) was conducted on baseline ratings from the Beck Depression Inventory (BDI), the Hamilton Depression Rating Scale (HAM-D), the Montgomery-Asberg Depression Rating Scale (MADRS), and the Snaith-Hamilton Pleasure Rating Scale (SHAPS). Inpatients with major depressive disorder (n = 76) or bipolar depr

SUBMITTER: Ballard ED 

PROVIDER: S-EPMC5852677 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature