Association of Circulating Vitamin E (α- and γ-Tocopherol) Levels with Gallstone Disease.

ABSTRACT: In addition to well-established risk factors like older age, female gender, and adiposity, oxidative stress may play a role in the pathophysiology of gallstone disease. Since vitamin E exerts important anti-oxidative functions, we hypothesized that circulating vitamin E levels might be inversely associated with prevalence of gallstone disease. In a cross-sectional study, we measured plasma levels of α- and γ-tocopherol using high performance liquid chromatography in a community-based sample (582 individuals; median age 62 years; 38.5% women). Gallstone disease status was assessed by ultrasound. Multivariable-adjusted logistic regression models were used to estimate the association of circulating α- and γ-tocopherol/cholesterol ratio levels with prevalent gallstone disease. Lower probabilit

SUBMITTER: Waniek S 

PROVIDER: S-EPMC5852709 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature