Modulation of miRNAs by Vitamin C in Human Bone Marrow Stromal Cells.

ABSTRACT: MicroRNAs (miRNAs) are small (18-25 nucleotides), noncoding RNAs that have been identified as potential regulators of bone marrow stromal cell (BMSC) proliferation, differentiation, and musculoskeletal development. Vitamin C is known to play a vital role in such types of biological processes through various different mechanisms by altering mRNA expression. We hypothesized that vitamin C mediates these biological processes partially through miRNA regulation. We performed global miRNA expression analysis on human BMSCs following vitamin C treatment using microarrays containing human precursor and mature miRNA probes. Bioinformatics analyses were performed on differentially expressed miRNAs to identify novel target genes and signaling pathways. Our bioinformatics analysis suggested that the m

SUBMITTER: Kolhe R 

PROVIDER: S-EPMC5852762 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature