How structural elements evolving from bacterial to human SLC6 transporters enabled new functional properties.

ABSTRACT: BACKGROUND:Much of the structure-based mechanistic understandings of the function of SLC6A neurotransmitter transporters emerged from the study of their bacterial LeuT-fold homologs. It has become evident, however, that structural differences such as the long N- and C-termini of the eukaryotic neurotransmitter transporters are involved in an expanded set of functional properties to the eukaryotic transporters. These functional properties are not shared by the bacterial homologs, which lack the structural elements that appeared later in evolution. However, mechanistic insights into some of the measured functional properties of the eukaryotic transporters that have been suggested to involve these structural elements are sparse or merely descriptive. RESULTS:To learn how the structural elemen

SUBMITTER: Razavi AM 

PROVIDER: S-EPMC5852957 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature